Research Triangle Park – In the first quarter of its fiscal year, the North Carolina Center for Biotechnology awarded 23 grants and loans totaling more than $1.4 million to bioscience companies, universities and nonprofits.
Held in July, August, and September, the awards support life sciences research, technology commercialization, and entrepreneurship throughout North Carolina. This funding will also help companies attract additional funding from other sources.
Three Bioscience Companies Win Awards small business research loan A total of $450,000 to facilitate research, product development and commercialization.
- coplata Durham University received $100,000 to help plan market access and reimbursement strategies. We also assisted a pilot program to provide patient feedback on a prototype automated stool sampling toilet. The company’s “smart toilet” technology is designed to analyze fecal biomarkers and other data to detect chronic gastrointestinal diseases such as inflammatory bowel disease.
- Angelna Biosciences Morrisville University received $250,000 to support in vivo validation of two lead treatment candidates for Huntington’s disease and myotonic dystrophy. The company uses its proprietary gene-editing platform to recognize and repair specific genetic defects responsible for over 40 known rare diseases.
- Animal Cancer Dx Raleigh University received $100,000 to develop a microfluidics-based screening test prototype and conduct validation studies. The company focuses on non-invasive methods of cancer screening in dogs using the highly sensitive olfactory system of the nematode C. elegans to detect volatile organic compounds in dog urine.
Portfolio companies raise $256 million
Biotech Center’s Life Science Intelligence Staff Survey Finds 25 Bioscience Companies Previously Loaned by the Biotech Center Raised $256 Million in Additional Funding from Other Sources in the First Quarter Did.
The majority of that total was from Greensboro. Piedmont Animal Healthwas sold to Dechra Pharmaceuticals of Northwich, UK in July for $210 million in cash. Over 20 years, Piedmont has developed more than 30 of his companion animal medicines sold by leading global brands.
Durham-based next-largest deal of the quarter Enteglion Raised approximately $13.9 million in venture capital. The company provides solutions for the clinical diagnosis and management of hemostasis, the body’s response to bleeding.
T3D Therapeutics Research Triangle Park has also raised over $6 million in venture capital, along with over $1 million in grants from the National Institutes of Health (NIH). The company is developing potential treatments for Alzheimer’s disease, Huntington’s disease and other neurodegenerative diseases.
epicypherAlso Research Triangle Park’s . The company develops reagents and tools to study chromatin regulation and enable epigenetics-focused drug development.
The university received a total of $863,093 in research grants from three programs.
2 Universities Win Innovation Impact Grant Total $243,927:
- The University of North Carolina at Chapel Hill received $148,182 to support the purchase of a state-of-the-art mass spectrometer for its biomarker mass spectrometry facility. This instrument allows the determination of metals in biological samples.
- The University of North Carolina, Wilmington (UNCW) received $95,745 to purchase a mass spectrometer upgrade for its Marine Science Core Facility. This upgrade will enable researchers to determine where specific compounds are localized in tissue and solid samples.
3 Universities Win Translational Research Grant Total $439,786:
- Duke University Medical Center received $109,837 to design and test an RNA-targeted drug to treat atherosclerosis, a leading cause of coronary artery disease and stroke.
- North Carolina State University received $110,000 to develop new methods of gene editing for use in gene therapy applications to treat a wide range of genetic diseases.
- UNCW received $109,949 to develop a method for preparing thermostable solutions of naked mRNA and mRNA-lipid nanoparticles. This eliminates the need for ultra-low temperature transport and storage of mRNA.
- UNCW also received $110,000 to develop a neck isometric assessment tool.
7 Universities Win flash grant Total $179,380:
- Duke University Medical Center received $11,714 to develop a humanized anti-gastrin-releasing peptide monoclonal antibody for potential treatment of pulmonary fibrosis and early lung injury and prevention of chronic lung disease.
- North Carolina received $18,753 to establish a new microspore culture system to create inbred tomato plants as a breeding stock.
- UNC Asheville received $23,359 to construct a library of S. aureus strains with controllable expression of functionally important genes important to etiology and drug discovery researchers.
- UNC-CH received $19,363 to develop a gene therapy for uveal melanoma that preserves vision and prevents metastasis.
- UNC Charlotte received $27,500 to further develop DNA and RNA-based nanoparticles that can deliver therapeutic agents to cells, such as delivery of antibiotics to treat bacterial meningitis.
- The University of North Carolina at Greensboro received $26,175 to develop a self-recharging battery made from live photosynthetic purple bacteria.
- UNCW received $26,258 to create a method to assemble protein pores through cell membranes for use in drug or antibiotic delivery.
- UNCW received $26,258 to develop a new daptomycin-related antibiotic with reduced toxicity and cost.
event and conference grants
Three universities and one nonprofit received grants totaling $28,250 Sponsor local events and national competitions in life sciences.
- Duke University Medical Center received $8,000 for “The Rulebreakers: Extraordinary Stories in Lipid Biology,” a conference on the impact of lipid and lipoprotein metabolism on the development and treatment of cardiometabolic disease. The conference also hosted a joint event with the NC Center for Diabetes Research to explore common themes of metabolic disease.
- North Carolina State University received $6,750 for the Food Animal Innovation Summit. The summit brings together industry and academic experts to exchange ideas and solutions in animal husbandry.
- UNC-CH received $6,500 for the Nanomedicine and Drug Delivery Symposium. This symposium is an annual event for researchers developing next-generation delivery vehicles, targeted and responsive biodegradable nanomaterials, to increase diagnostic sensitivity and make drugs more effective.
- UNC-CH received $5,000 for the 3rd Annual Interdisciplinary Symposium on Nutritional Sciences, “Diet and Chronic Unresolved Inflammation: Implications for Obesity-Related Outcomes.” The symposium addressed the critical need for a rigorous interdisciplinary and translational approach to diet and nutrition to prevent and treat chronic inflammation associated with metabolic diseases.
- Sigma Xi, the Scientific Research Honor Society received $2,000 for the NC Science Policy Bootcamp. This bootcamp is his four-day interactive forum that introduces participants to science policy alongside his top leaders in science, industry, and government.
Partnership Development Grant
NCBiotech awarded the City of Greenville a $100,000 partnership development grant to expand the Pharma K12 program. Offers a local high school graduate the opportunity to train in her NC Pharmaceutical Services Network at Pitt Community College (PSN@PCC) and a job interview at Thermo Fisher Scientific. The expansion of the program will strengthen the talent pipeline and community involvement in Pitt County as Thermo Fisher Scientific plans to add 290 jobs to its Greenville manufacturing facility.
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